Lupus anticoagulant and leg ulcers in sickle cell anemia

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Leg ulcers in sickle cell disease.

Sickle cell disease is a single amino acid molecular disorder of hemoglobin leading to its pathological polymerization, red cell rigidity that causes poor microvascular blood flow, with consequent tissue ischemia and infarction. The manifestations of this disease are protean.Among them, leg ulcers represent a particularly disabling and chronic complication, often associated with a more severe c...

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Infrared (IR) imaging and Laser Speckle Contrast Imaging (LSCI) were used to measure skin temperature and blood flow, respectively, in leg ulcers of sickle cell anemia patients. Regional maps of the power of oscillations were computed via Fast Fourier Transform within the ulcers and surrounding tissues. We hypothesize that measurements of regional oscillations of temperature and perfusion by IR...

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Leg ulcers in severity of sickle cell diseases

Objective : Background: We tried to understand whether or not there are some positive correlations between leg ulcers and severity of sickle cell diseases (SCDs). Methods: All patients with SCDs were taken into the study. Results: The study included 346 patients with the SCDs (175 males). There were 50 cases (14.4%) with leg ulcers. Interestingly, the male ratio was significantly higher in pati...

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Leg ulceration is a common and painful complication of sickle cell anemia (SS). Leg ulcers tend to be indolent and intractable and heal slowly over months or years. The pain of these ulcers may be severe, excruciating, penetrating, sharp, and stinging in nature. In most patients, oral or parenteral opioid analgesics may be needed to achieve some pain relief. We wish to report our experience wit...

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ژورنال

عنوان ژورنال: Indian Journal of Dermatology

سال: 2009

ISSN: 0019-5154

DOI: 10.4103/0019-5154.55635